Left-handed pitcher Alonzo Tredwell from UCLA was the first Southern California collegiate taken in the 2023 Major League Baseball draft. Tredwell was taken 22nd in the second round (61st overall) by the Houston Astros.
San Diego State outfielder / catcher Cole Carrigg was the next college player from the region taken, picked four slots later by the Colorado Rockies in a bonus round at the end of the second round.
Other players from Southern California four-year colleges and universities taken during the draft were:
- Connor Burns, a catcher from Long Beach State, taken in the fifth round (141st pick overall) by the Cincinnati Reds
- Kyle Karros, a third baseman from UCLA, also taken in the fifth round (145), by the Rockies
- Kevin Sim, a third baseman from the University of San Diego, went three picks later to the Arizona Diamondbacks
- Lucas Braun, a right-handed pitcher from Cal State Northridge, was picked 25th in the sixth round (189) by the Atlanta Braves
- Nate Nankil, an outfielder at Cal State Fullerton, went with the second pick of the seventh round (196) to the Oakland A’s
- John Peck, a Pepperdine shortstop, was taken four picks later by Detroit
- Charles Harrison, a right-handed pitcher out of UCLA, had his name called by the St. Louis Cardinals with the 21st pick of the seventh round (215)
- Ryan Johnson, a second baseman at Pepperdine, was the last pick of the eighth round (254), going to the Astros
- Jonathon Long, a Long Beach State first baseman, went to the Chicago Cubs with the 12th pick of the ninth round (266)
- Graham Osman, a left-handed hurler out of Long Beach State, went to the Reds with the fourth pick of the 10th round (288)
- Caden Kendle, an outfielder at UC Irvine, was taken by St. Louis with the 21st pick of the 10th round (305)
- Jared Sundstrom, an outfielder at UC Santa Barbara, went two picks later to the Seattle Mariners
- Jake Brooks, a right-handed pitcher out of UCLA, was taken by the Miami Marlins with the ninth pick of the 11th round (323)
- Jojo Ingrassia, a left-handed pitcher at Fullerton, went to the Boston Red Sox with the 14th pick of the 14th round (418)
- T.J. Fondtain, a two-way player from SDSU (LH pitcher, outfielder), was picked by Tampa Bay Rays five picks later (423)
- Darius Perry, a UCLA catcher, was selected with the eighth pick of the 15th round by Colorado
- Spencer Bengard, a right-handed pitcher at Cal Baptist, was taken five picks later by the Minnesota Twins
- Kelena Sauer, a right-handed pitcher for San Diego State, had his name called in the 20th spot of the 15th round (454) by the Toronto Blue Jays
- Jared Thomas, a catcher from Loyola Marymount, was picked in the 29th slot of the round by the Philadelphia Phillies
- Cole Urman, a CSU Fullerton catcher, was selected 17th in the 16th round (481) by the Baltimore Orioles
- Sam Whiting, a right-handed pitcher out of UCSB, was taken by the Padres 10 slots later (491)
- Merrick Baldo, a Loyola Marymount right-handed pitcher, was taken with the first pick of the 17th round by the Washington Nationals.
- Ethan Flanagan, a southpaw pitcher for UCLA, was chosen with the 12th pick of the round (506) by the Cubs.
- Hector Garcia Jr., a right-handed pitcher out of Hope International University, was taken No. 13 of the 18th round (537) by the Twins.
- Johnny Olmstead, third baseman for the USC Trojans, went to the Marlins with the ninth pick of the 19th round (563)
- Caden Connor, outfielder at Cal State Fullerton, was picked 15th in that round (569) by the Chicago White Sox
- Graysen Tarlow, a catcher at Cal State Northridge, went six picks later to the Cardinals
- Diego Barrera, a left-handed pitcher for Loyola Marymount, was taken second in the 20th (and final) round (586) by Oakland
UCLA led all Southern California schools with 6 players taken in the draft. Cal State Fullerton saw four players’ names called, while Long Beach State, Loyola Marymount and San Diego State each had three taken.